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Postdoctoral fellowship in basic and translational atherothrombosis and vascular biology

University of South Florida - USF Health


Location:
Tampa, FL
Date:
12/06/2017
2017-12-062018-01-06
Job Code:
100446924
University of South Florida - USF Health
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Job Details

The USF Health Heart Institute
Morsani College of Medicine
University of South Florida, Tampa, Florida, USA

Postdoctoral fellowship in basic and translational atherothrombosis and vascular biology

Summary

Immediate opening for one PhD postdoctoral candidate to join a highly translational molecular imaging and nanotherapy group. The position is open to both US graduates and International candidates with appropriate visa status. The appointee(s) will have earned a Ph.D., in molecular biology, physiology, biochemistry, pathology, or other related basic science disciplines with a specific background in vascular biology and the pathophysiology and mechanisms of atherothrombosis. Experience with in vivo experimental preparations of standard models of atherosclerosis (e.g.,ApoE null, LDLR null, etc..) and thrombosis (dye-laser injury, ferric chloride, etc.), and surgical preparations in rodents (wire injury, cuff stenosis, etc.) is required. Experience with in vitro preparations of vascular cell types, especially endothelium, for elucidation of inflammatory molecular signaling events and response to pharmacological interventions is critical for evaluation of novel nanotherapeutics. Experience with production and testing of genetically engineered mice for evaluation of critical signaling pathways will be useful as well. Opportunities exist for participation in multiple ongoing NIH-sponsored projects including but not limited to:

  • The development and testing of nanoparticle-based approaches for prevention of plaque destabilization, atherothrombosis, and plaque development, including delivery of siRNA, miRNA, mRNA, and DNA with novel peptide-based oligonucleotide nanostructures
  • The role of inflammation and macrophages-endothelial cross talk in production of vulnerable and disrupted plaque, endothelial barrier disruption, and plaque healing
  • Detection of disrupted and procoagulant plaques with image-based biomarkers for MRI, ultrasound, and nuclear imaging using conventional and novel targeted contrast agents

The selected candidate is expected to work independently, with other lab members, and under general supervision of collaborating PI(s), in concert with the Principal Investigator to move the project(s) forward effectively. The selected candidate may be responsible for the following activities: develop and implement research strategies based on thorough and rigorous literature reviews; develop and modify research protocols; manage data entry and storage; prepare research protocols, reports, abstracts, and manuscripts; attend international meetings; mentor junior members of the lab and students in vascular biology methodologies

Preferred Qualifications

  • Strong organization skills and significant attention to detail
  • Outstanding strategic thinking, planning and communications skills
  • Self-motivated and able to initiate necessary actions without instruction
  • Ability to remain on-task and simultaneously manage multiple aspects of the daily workload
  • Ability to work both independently and with a team, resolving issues promptly and with a positive outcome
  • Very high level of integrity, ethics and professionalism
  • Very strong verbal and written communication skills and computer skills
  • Respect for peers and team members

The Principal Investigator

Dr. Samuel Wickline M.D., Professor of Cardiovascular Science, TGH Endowed Chair of Cardiovascular Medicine, Director of University of South Florida (USF) Health Heart Institute, and Interim DIrector of the Department of Cardiovascular Sciences joined the USF in December 2016 and brings active research programs from Washington University School of Medicine in St. Louis. The USF Heart Institute brings together a critical mass of basic science, translational, and clinical researchers to address unmet medical needs related to cardiovascular disease (CVD), the number one killer of Americans today. Dr. Wickline's laboratory, funded by NIH, is a multidisciplinary basic and applied research environment and training venue with a translational focus. Our research activities cross many Departments, Schools, and Institutions to create and deploy new diagnostic imaging and therapeutic technologies for myriad diseases including cardiovascular, cancer, hematology, renal, pulmonary, infection, metabolism, gastrointestinal, orthopedic, gynecological, among others. Graduate students and postdoctoral fellows are represented from diverse Departments including Biomedical Engineering, Physics, Medicine, Pathology, Molecular and Cellular Biology, and Computational Biology among others. Please see: http://health.usf.edu/medicine/cardiology/faculty/2871501/Wickline

Information regarding Staff and Administration benefits can be found by visiting the following website: http://www.usf.edu/work-at-usf/benefits/

In order to apply for this position, please visit the USF Careers website (http://www.usf.edu/work-at-usf/careers/) and click on “Access Careers@USF.” From there, search for job ID 15104 and follow the directions listed in the posting to apply. Please make sure to upload your cover letter and CV. Three references will be requested for promising candidates (one reference must be current your current supervisor) after initial review

USF is an equal opportunity, equal access academic institution that embraces diversity in the workplace

PI100446924

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